Genetic Polymorphism of Malaria PkDBPaII
Work
This research investigates the genetic diversity and erythrocyte binding activity of Plasmodium knowlesi Duffy Binding Protein Alpha Region II (PkDBPαII), particularly focusing on samples collected from various regions of Malaysia between 2019 and 2021. The project involved molecular techniques like PCR amplification, DNA sequencing, and phylogenetic analysis to study the PkDBPαII gene. Additionally, erythrocyte binding assays (EBA) were conducted to determine the binding activity of PkDBPαII.
The genetic analysis did not reveal any novel polymorphisms in the PkDBPαII sequences from recent years, but the binding activity varied between isolates from different regions and parasitaemia levels.
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